Haematological complications of X-linked lymphoproliferative syndrome type 1 and 2
نویسندگان
چکیده
منابع مشابه
Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency).
X-linked lymphoproliferative syndromes (XLP) are primary immunodeficiencies characterized by a particular vulnerability toward Epstein-Barr virus infection, frequently resulting in hemophagocytic lymphohistiocytosis (HLH). XLP type 1 (XLP-1) is caused by mutations in the gene SH2D1A (also named SAP), whereas mutations in the gene XIAP underlie XLP type 2 (XLP-2). Here, a comparison of the clini...
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1 Molecular and Cellular Immunology Section, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, 2 Department of Pediatric Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 3 National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States, 4 National Institute of ...
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ژورنال
عنوان ژورنال: Pediatric Hematology/Oncology and Immunopathology
سال: 2020
ISSN: 2414-9314,1726-1708
DOI: 10.24287/1726-1708-2020-19-3-62-72